EGR3 polymorphism is a potential susceptibility factor of schizophrenia risk in a Chinese population.

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dc.contributor.authorBi, Wen
dc.contributor.authorLi, Jingjing
dc.contributor.authorXiong, Mengqiu
dc.contributor.authorLubanga, Nasifu
dc.contributor.authorTan, Mingjuan
dc.contributor.authorTai, Ping
dc.contributor.authorJin, Qing
dc.contributor.authorZhang, Lingyun
dc.contributor.authorZhu, Chengbin
dc.contributor.authorHe, Bangshun
dc.date.accessioned2024-11-20T09:02:26Z
dc.date.available2024-11-20T09:02:26Z
dc.date.issued2024-04-24
dc.description.abstractObjective: The purpose of this study was to evaluate the association between the single nucleotide polymorphisms (SNPs) (EGR3 rs1996147; EGR4 rs3813226, rs6747506; ERBB3 rs2292238; and ERBB4 rs707284, rs7560730) and the risk of schizophrenia (SZ) in a Chinese population. Materials and Methods: We conducted a case–control study, including 248 patients with SZ and 236 healthy controls matched for age and sex. The Mass-array platform was used to detect all the genotypes of the SNPs. Results: The results revealed that the EGR3 rs1996147 AA genotype was associated with borderline decreased SZ risk (AA vs. GG: adjusted OR = 0.43, 95% CI: 0.18–1.02, p = 0.06). However, no significant correlation was found between the other SNPs and overall SZ risk. Subgroup analysis also failed to show any significant association between all SNPs and the risk of SZ. Conclusion: In summary, this study revealed that the EGR3 rs1996147 AA genotype was associated with a borderline risk for SZ.
dc.description.sponsorshipJiangsu Provincial Medical Key Discipline Cultivation Unit (JSDW202239).
dc.identifier.citationBi, W., Li, J., Xiong, M., Nasifu, L., Tan, M., Tai, P., ... & He, B. (2024). EGR3 polymorphism is a potential susceptibility factor of schizophrenia risk in a Chinese population. Genetic Testing and Molecular Biomarkers, 28(4), 144-150.
dc.identifier.issn1945-0257
dc.identifier.urihttps://dir.muni.ac.ug/handle/20.500.12260/704
dc.language.isoen
dc.publisherMary Ann Liebert
dc.subjectschizophrenia
dc.subjectpolymorphism
dc.subjectsingle nucleotide polymorphisms
dc.subjectgenotypes
dc.titleEGR3 polymorphism is a potential susceptibility factor of schizophrenia risk in a Chinese population.
dc.typeArticle

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