EGR3 polymorphism is a potential susceptibility factor of schizophrenia risk in a Chinese population.
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Date
2024-04-24
Journal Title
Journal ISSN
Volume Title
Publisher
Mary Ann Liebert
Abstract
Objective: The purpose of this study was to evaluate the association between the single nucleotide polymorphisms (SNPs) (EGR3 rs1996147; EGR4 rs3813226, rs6747506; ERBB3 rs2292238; and ERBB4 rs707284, rs7560730) and the risk of schizophrenia (SZ) in a Chinese population.
Materials and Methods: We conducted a case–control study, including 248 patients with SZ and 236 healthy controls matched for age and sex. The Mass-array platform was used to detect all the genotypes of the SNPs.
Results: The results revealed that the EGR3 rs1996147 AA genotype was associated with borderline decreased SZ risk (AA vs. GG: adjusted OR = 0.43, 95% CI: 0.18–1.02, p = 0.06). However, no significant correlation was found between the other SNPs and overall SZ risk. Subgroup analysis also failed to show any significant association between all SNPs and the risk of SZ.
Conclusion: In summary, this study revealed that the EGR3 rs1996147 AA genotype was associated with a borderline risk for SZ.
Description
Keywords
schizophrenia, polymorphism, single nucleotide polymorphisms, genotypes
Citation
Bi, W., Li, J., Xiong, M., Nasifu, L., Tan, M., Tai, P., ... & He, B. (2024). EGR3 polymorphism is a potential susceptibility factor of schizophrenia risk in a Chinese population. Genetic Testing and Molecular Biomarkers, 28(4), 144-150.