Browsing by Author "Xiong, Mengqiu"

Now showing 1 - 4 of 4
  • Thumbnail Image
    Item
    The correlation between equatorial electrojet and equatorial ionisation anomaly over the East African region during the solar minimum period 2008-2009
    (East African Journal Of Science, Technology and Innovation, 2023-09-29) Xiong, Mengqiu; Milimu, Hannington; Omondi, George; Mungufeni, Patrick
    This study analyzed the correlation between the equatorial electrojet (EEJ) and the occurrence of equatorial ionisation anomaly (EIA) over the East African region. The study was carried out during both geomagnetically quiet and disturbed conditions when Kp index values were < 2+ and > 5+, respectively. The EEJ data were obtained using a pair of magnetometers located at Adis Ababa (geographic 9.04°N, 38.77°E, geomagnetic 0.17°N, 110.47°E) and Adigrat (geographic 14.281°N, 39.46°E, geomagnetic 6.0°N, 111.06°E), both in Ethiopia while the EIA data were derived from the total electron content (TEC) data that were obtained using a set of Global Navigation Satellite System (GNSS) receivers within the East African region. The data used were for the years 2008 and 2009. The TEC data over the crest of EIA were divided by those over the trough to quantify EIA strength over the region. The EEJ intensity was estimated from the difference in the horizontal component of the geomagnetic field observed by the pair of magnetometers. The results during quiet geomagnetic conditions showed that peak values of EEJ which range from 48nT - 110nT occurred between 10:00 and 14:00 LT. The EIA’s peak which varies from 1.20 to 1.45 occurs between 20:00 to 22:00 LT. The correlation coefficients were found to vary from moderate (0.58) to strongest (0.74). During geomagnetically disturbed conditions, the correlation coefficient ranges from 0.28 to 0.45. The increased eastward electric field and photo-ionization on TEC are responsible for the strong link between EEJ and EIA. This study reveals the trend in the variation of the strength of EEJ and EIA over the East African region which can be used as a basis for developing regional models to forecast or nowcast scintillations and the ionospheric space weather prediction over this region.
  • Thumbnail Image
    Item
    The diagnostic and prognostic role of miR-27a in cancer
    (Elsevier, 2023-05-22) Bi, Wen; Li, Jingjing; Xiong, Mengqiu; Pan, Bei; Zhang, Zhongqiu; Lubanga, Nasifu; He, Bangshun; Wang, Ping
    MicroRNA-27a (miR-27a) has been reported to be abnormally expressed in patients with cancer, and it could play potential roles as a diagnostic and prognostic biomarker of cancers. However, the diagnostic and prognostic role remains unclear. Hence, this meta-analysis, based on published data, was conducted to assess the utility of miR-27a as a diagnostic and prognostic marker in various cancers. To identify eligible studies, databases: Web of Science, PubMed, and CNKI were searched, with 868 literatures obtained, 16 of which were included in the Meta-analysis. The pooled results of studies conducted with serum/plasma showed that miR-27a was a valuable diagnostic biomarker in cancers (area under curve (AUC)= 0.91, sensitivity (SEN)= 0.84, specificity (SPE)= 0.85), with the diagnostic value slightly reduced in tumor tissue samples (AUC=0.83, SEN=0.78, SPE: 0.74). Additionally, the pooled results revealed that high expression of miR-27a predicted poor prognosis of cancer in serum/plasma (hazard ratio (HR) = 0.63, PHeterogeneity = 0.278, I2= 21.50%) but not in tumor tissue (HR = 0.98, PHeterogeneity =0.577, I2= 0.0). In brief, our results suggested that miR-27a in serum/plasma or tumor tissue could act as a diagnostic biomarker, and that miR-27a in serum/plasma could predict cancer patients’ survival.
  • Thumbnail Image
    Item
    EGR3 polymorphism is a potential susceptibility factor of schizophrenia risk in a Chinese population.
    (Mary Ann Liebert, 2024-04-24) Bi, Wen; Li, Jingjing; Xiong, Mengqiu; Lubanga, Nasifu; Tan, Mingjuan; Tai, Ping; Jin, Qing; Zhang, Lingyun; Zhu, Chengbin; He, Bangshun
    Objective: The purpose of this study was to evaluate the association between the single nucleotide polymorphisms (SNPs) (EGR3 rs1996147; EGR4 rs3813226, rs6747506; ERBB3 rs2292238; and ERBB4 rs707284, rs7560730) and the risk of schizophrenia (SZ) in a Chinese population. Materials and Methods: We conducted a case–control study, including 248 patients with SZ and 236 healthy controls matched for age and sex. The Mass-array platform was used to detect all the genotypes of the SNPs. Results: The results revealed that the EGR3 rs1996147 AA genotype was associated with borderline decreased SZ risk (AA vs. GG: adjusted OR = 0.43, 95% CI: 0.18–1.02, p = 0.06). However, no significant correlation was found between the other SNPs and overall SZ risk. Subgroup analysis also failed to show any significant association between all SNPs and the risk of SZ. Conclusion: In summary, this study revealed that the EGR3 rs1996147 AA genotype was associated with a borderline risk for SZ.
  • Thumbnail Image
    Item
    Prognostic role of E2F1 gene expression in human cancer: a meta-analysis
    (BioMed Central, 2023-06-05) Li, Jingjing; Bi, Wen; Lu, Fang; Pan, Bei; Xiong, Mengqiu; Lubanga, Nasifu; Nie, Zhenlin; He, Bangshun
    E2F1 has been confirmed to be highly expressed in a variety of cancers. To better understand the prognostic value of E2F1 in cancer patients, this study was conducted to comprehensively evaluate the prognostic value of E2F1 in cancer according to published data. PubMed, Web of Science and CNKI database were searched until May 31st, 2022 using keywords to retrieve the published essays on the role of E2F1 expression in the prognostic value of cancer. The essays were identified according to the inclusion and exclusion criteria. The pooled result of the hazard ratio and 95% confidence interval was calculated with Stata17.0 software. A total of 17 articles were included in this study involved in 4481 cancer patients. The pooled results showed that higher E2F1 expression was significantly correlated with unfavorable overall survival (HR = 1.10, I2 = 95.3%, *PHeterogeneity = 0.000) and disease-free survival (HR = 1.41, I2 = 95.2%, *PHeterogeneity = 0.000) of cancer patients. Such a significant association of was maintained subgroup of sample size of patients (> 150: for OS, HR = 1.77, and for DFS, HR = 0.91; or < 150: for OS, HR = 1.93, and for DFS, HR = 4.39), ethnicity (Asian: for OS, HR = 1.65, and for DFS, HR = 1.08; or not Asian: HR = 3.55, and for DFS, HR = 2.87), the data from database (clinical: for OS, HR = 1.24, and for DFS, HR = 1.40; or database: for OS, HR = 2.29, and for DFS, HR = 3.09), paper published year (after 2014: for OS, HR = 1.90;and for DFS,HR = 1.87; or before 2014: for OS, HR = 1.40, and for DFS, HR = 1.22); cancer type (female specific cancer: for OS, HR = 1.41, and for DFS, HR = 0.64; or non-gender specific cancers: for OS, HR = 2.00, and for DFS, HR = 2.95). In addition, according to the database data, we also found that higher E2F1 expression level would lead to worse prognosis of patients, and the results were consistent with the statistical analysis results in the paper.