Effect of community awareness, screening, testing, and treatment campaigns on TB prevention.

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dc.contributor.authorMulebeke, R
dc.contributor.authorIzudi, Jonathan
dc.contributor.authorAgaba, S.
dc.contributor.authorwalatum, J.E.O.
dc.contributor.authorJaganath, D.
dc.date.accessioned2026-03-23T20:05:08Z
dc.date.available2026-03-23T20:05:08Z
dc.date.issued2026-02-27
dc.descriptionThis paper aligns with SDG 3 (Good Health and Well-Being) by advancing TB prevention among high-risk groups, and NDP IV by strengthening community-based health service delivery. Its contribution includes evidence that integrated CAST-TB campaigns significantly improve preventive treatment uptake, supporting Uganda’s goals of reducing TB burden and enhancing universal health coverage through decentralized, person-centered care.
dc.description.abstractBackground: Tuberculosis preventive treatment (TPT) is a critical intervention for reducing TB incidence among high-risk groups, including people with HIV (PWH) and household contacts (HHCs). Despite its effectiveness, global TPT coverage remains suboptimal, particularly in high-burden settings like Uganda. Objective: To evaluate the effect of community-based CAST-TB campaigns on TPT initiations among PWH and HHCs in central Uganda. Methods: This single-group interrupted time series analysis used de-identified, aggregated TPT data from 105 TB clinics across eight districts in central Uganda (January 2020–December 2021). The intervention phase (2021) was compared with a pre-intervention phase (2020) using Bayesian Structural Time Series modeling to estimate pointwise and cumulative causal effects. Results: Among HHCs, TPT initiations increased by 1,853 (95% CrI: 1,102–2,691), representing a relative increase of 121% (95% CrI: 72–176; p = 0.001). Among PWH, initiations increased by 1,346 (95% CrI: –729 to 3,680), with a relative increase of 12% (95% CrI: –6.3–32; p = 0.069), which was not statistically significant. Children under five years experienced a significant relative increase of 84% (95% CrI: 68–102; p = 0.001). Conclusion: CAST-TB campaigns significantly improved TPT initiation among HHCs and young children, with more modest effects among PWH. Community-based, integrated campaigns can enhance TPT uptake in resource-limited settings. Sustaining gains will require strengthening follow-up systems and ensuring uninterrupted TPT supply.
dc.description.sponsorshipPresident's Emergency Plan for AIDS Relief (PEPFAR).
dc.identifier.citationMulebeke, R., Izudi, J., Agaba, S., Bwalatum, J. E. O., & Jaganath, D. (2026). Effect of community awareness, screening, testing, and treatment campaigns on TB prevention. The international journal of tuberculosis and lung disease: the official journal of the International Union against Tuberculosis and Lung Disease, 30(3), 137-141.
dc.identifier.issn1815-7920
dc.identifier.urihttps://dir.muni.ac.ug/handle/20.500.12260/944
dc.language.isoen
dc.publisherInternational Union Against Tuberculosis and Lung Disease
dc.subjectCAST-TB
dc.subjectHIV
dc.subjectTBI
dc.subjectTPT
dc.subjectUganda
dc.subjectTuberculosis
dc.titleEffect of community awareness, screening, testing, and treatment campaigns on TB prevention.
dc.typeArticle

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