Dyslipidemia and associated factors among people living with HIV on dolutegravir-based antiretroviral therapy in central Uganda

Simple item page
dc.contributor.authorTimbigamba, Flavia
dc.contributor.authorBagenda, Charles Nkubi
dc.contributor.authorSembogga, Hendry
dc.contributor.authorWasswa, Timothy
dc.contributor.authorBazibu, Faizo
dc.contributor.authorSsali, Joseph
dc.contributor.authorSsemwanga, Elastus
dc.contributor.authorMugisa, Michael Junior
dc.contributor.authorNuwagaba, Edwin
dc.contributor.authorOjuko, Samuel
dc.contributor.authorNantongo, Carol
dc.contributor.authorWafwoyo, Jesca Akoth
dc.contributor.authorMusinguzi, Benson
dc.contributor.authorAkiteng, Winnie
dc.contributor.authorOsuwat, Lawrence Obado
dc.date.accessioned2025-11-14T09:30:56Z
dc.date.available2025-11-14T09:30:56Z
dc.date.issued2025-10-23
dc.description.abstractIntroduction Dolutegravir (DTG)-based antiretroviral therapy (ART) use has been associated with excessive weight gain, increasing the risk of dyslipidemias such as hypercholesterolemia. We assessed the prevalence of, and associated factors with dyslipidemia among adults on DTG-based ART. Materials and methods We conducted a cross-sectional study among 281 systematically sampled adults on DTG-based ART for ≥ 6 months at Kira Health Centre IV, Wakiso District, Central Uganda. Data were collected through structured questionnaires, medical record reviews, anthropometric measurements, and laboratory biomarker analysis. Logistic regression was used to determine associated factors, and the predictive performance of obesity indices was evaluated using receiver operating characteristic (ROC) curve analysis. Results The prevalence of dyslipidemia was 44.1% 95% CI: 38.4%–50.0%. Low high-density lipoprotein (HDL) cholesterol was the most common abnormality, affecting 39.9% of participants, followed by elevated total cholesterol at 5.7% [95% CI: 3.51–9.11] and elevated low-density lipoprotein (LDL) cholesterol at 5.0%. High waist circumference (WC) was significantly associated with dyslipidemia; (aPR: 1.93, 95% CI: 1.15–3.24, p = .013), and demonstrated a significant ability to predict dyslipidemia with area under the curve (AUC) of 0.577 [95% CI: 0.511–0.644]. The AUC for WC in predicting hypercholesterolemia, elevated LDL-C, and low HDL-C were 0.702 (95% CI: 0.547–0.857), 0.729(95% CI: 0.590–0.867), and 0.548 (95% CI: 0.481–0.616) respectively. Conclusion Dyslipidemia is prevalent among adults on DTG-based ART, and is potentially associated with high WC.
dc.identifier.citationTimbigamba, F., Bagenda, C.N, Sembogga, H., Wasswa, T., Bazibu, F., Ssali, J., Ssemwanga, E., Mugisa, M.J., Nuwagaba, E., Ojuko, S., Nantongo, C., Wafwoyo, J.,A., Musinguzi, B., Akiteng, W. & Osuwat, L.O. (2025). Dyslipidemia and associated factors among people living with HIV on dolutegravir-based antiretroviral therapy in central Uganda. Journal of the International Association of Providers of AIDS Care (JIAPAC), 24: 1-14.
dc.identifier.issn2325-9582
dc.identifier.urihttps://dir.muni.ac.ug/handle/20.500.12260/805
dc.language.isoen
dc.publisherSAGE Publications
dc.subjectDolutegravir
dc.subjectHIV
dc.subjectAntiretroviral therapy
dc.subjectObesity indices
dc.subjectWeight gain
dc.subjectDyslipidemia
dc.titleDyslipidemia and associated factors among people living with HIV on dolutegravir-based antiretroviral therapy in central Uganda
dc.typeArticle

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Musinguzi_Article_2025_23102025.pdf
Size:
1.42 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
4.17 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Research Articles