Dyslipidemia and associated factors among people living with HIV on dolutegravir-based antiretroviral therapy in central Uganda
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Date
2025-10-23
Journal Title
Journal ISSN
Volume Title
Publisher
SAGE Publications
Abstract
Introduction
Dolutegravir (DTG)-based antiretroviral therapy (ART) use has been associated with excessive weight gain, increasing the risk of dyslipidemias such as hypercholesterolemia. We assessed the prevalence of, and associated factors with dyslipidemia among adults on DTG-based ART.
Materials and methods
We conducted a cross-sectional study among 281 systematically sampled adults on DTG-based ART for ≥ 6 months at Kira Health Centre IV, Wakiso District, Central Uganda. Data were collected through structured questionnaires, medical record reviews, anthropometric measurements, and laboratory biomarker analysis. Logistic regression was used to determine associated factors, and the predictive performance of obesity indices was evaluated using receiver operating characteristic (ROC) curve analysis.
Results
The prevalence of dyslipidemia was 44.1% 95% CI: 38.4%–50.0%. Low high-density lipoprotein (HDL) cholesterol was the most common abnormality, affecting 39.9% of participants, followed by elevated total cholesterol at 5.7% [95% CI: 3.51–9.11] and elevated low-density lipoprotein (LDL) cholesterol at 5.0%. High waist circumference (WC) was significantly associated with dyslipidemia; (aPR: 1.93, 95% CI: 1.15–3.24, p = .013), and demonstrated a significant ability to predict dyslipidemia with area under the curve (AUC) of 0.577 [95% CI: 0.511–0.644]. The AUC for WC in predicting hypercholesterolemia, elevated LDL-C, and low HDL-C were 0.702 (95% CI: 0.547–0.857), 0.729(95% CI: 0.590–0.867), and 0.548 (95% CI: 0.481–0.616) respectively.
Conclusion
Dyslipidemia is prevalent among adults on DTG-based ART, and is potentially associated with high WC.
Description
Keywords
Dolutegravir, HIV, Antiretroviral therapy, Obesity indices, Weight gain, Dyslipidemia
Citation
Timbigamba, F., Bagenda, C.N, Sembogga, H., Wasswa, T., Bazibu, F., Ssali, J., Ssemwanga, E., Mugisa, M.J., Nuwagaba, E., Ojuko, S., Nantongo, C., Wafwoyo, J.,A., Musinguzi, B., Akiteng, W. & Osuwat, L.O. (2025). Dyslipidemia and associated factors among people living with HIV on dolutegravir-based antiretroviral therapy in central Uganda. Journal of the International Association of Providers of AIDS Care (JIAPAC), 24: 1-14.