Association between atherogenic index of plasma and prehypertension or hypertension among normoglycemia subjects in a Japan population: a cross-sectional study

dc.contributor.authorTan, Mingjuan
dc.contributor.authorZhang, Yongliang
dc.contributor.authorJin, Ling
dc.contributor.authorWang, Youli
dc.contributor.authorCui, Weiwei
dc.contributor.authorLubanga, Nasifu
dc.contributor.authorHe, Bangshun
dc.date.accessioned2023-07-23T21:53:42Z
dc.date.available2023-07-23T21:53:42Z
dc.date.issued2023-06-29
dc.description.abstractThe atherogenic index of plasma (AIP), consisting of triglycerides and high-density lipoprotein cholesterol, is applied to estimate the cardiovascular disease risk. The evidence regarding the association between AIP and prehypertension or hypertension remains inconclusive. This study was conducted to investigate the association of AIP and prehypertension or hypertension in normoglycemic subjects in Japan. In the present cross-sectional study, 15,453 normoglycemic participants aged 18 years or older in Gifu, Japan, were evaluated. The selected participants were separated into four groups in the light of AIP quartiles, ranging from the lowest quartile (Q1) to the highest quartile (Q4). And the association between AIP and prehypertension or hypertension was explored with multivariate logistic regression by gradually adjusting model. Among the 15,453 participants, aged of 43.7 ± 8.9 years, and of whom 45.5% were females, the prevalence rates of prehypertension or hypertension were 27.68% (4,278) and 6.23% (962) respectively. In multivariate logistic regression analyses, participants in the highest AIP quartile had an increase risk in prehypertension and hypertension, compared with participants the lowest one, the odds ratios (OR) were 1.15 (95%CI: 1.00–1.13, P = 0.045) for prehypertension and 1.54 (95%CI:1.16–2.04, P = 0.003) for hypertension after adjusting confounders. In subgroup analyses, the high risk of hypertension was also observed for female participants in the highest AIP quartile (Q4) (OR = 2.19, 95%CI: 1.37–3.49, P = 0.001), especially between the ages of 40 and 60 years (OR = 2.20, 95%CI: 1.24–3.88, P = 0.007). Conclusions Higher AIP is significantly and positively associated with the risk of prehypertension or hypertension in normoglycemic subjects in Gifu, Japan, which was more pronounced in the female population, especially between the years of 40 and 60.en_US
dc.description.sponsorshipJiangsu Provincial Medical Key Discipline Cultivation Unit (JSDW202239)en_US
dc.identifier.citationTan, M., Zhang, Y., Jin, L., Wang, Y., Cui, W., Lubanga, N., He, B. (2023). Association between atherogenic index of plasma and prehypertension or hypertension among normoglycemia subjects in a Japan population: a cross-sectional study. Lipids in Health and Disease, 22(1), 1-11.en_US
dc.identifier.issn1476-511X
dc.identifier.urihttps://dir.muni.ac.ug/handle/20.500.12260/548
dc.language.isoenen_US
dc.publisherSpringer Natureen_US
dc.subjectAtherogenic index of plasma (AIP)en_US
dc.subjectPrehypertensionen_US
dc.subjectHypertensionen_US
dc.subjectNormoglycemiaen_US
dc.titleAssociation between atherogenic index of plasma and prehypertension or hypertension among normoglycemia subjects in a Japan population: a cross-sectional studyen_US
dc.typeArticleen_US

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