Mutactimycin AP, a new mutactimycin isolated from an actinobacteria from the Atacama Desert

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dc.contributor.authorAstakala, Rishi Vachaspathy
dc.contributor.authorPreet, Gagan
dc.contributor.authorMilne, Bruce F.
dc.contributor.authorTibyangye, Julius
dc.contributor.authorRazmilic, Valeria
dc.contributor.authorCastro, Jean Franco
dc.contributor.authorAsenjo, Juan A.
dc.contributor.authorAndrews, Barbara
dc.contributor.authorEbel, Rainer
dc.contributor.authorJaspars, Marcel
dc.date.accessioned2022-10-24T11:16:55Z
dc.date.available2022-10-24T11:16:55Z
dc.date.issued2022-10-24
dc.description.abstractBacteria belonging to the phylum Actinobacteria are a very good source of antibiotics, and indeed dominate the current clinical antibiotic space. This paper reports Mutactimycin AP, a new compound belonging to an anthracycline-type family of antibiotics, isolated from a Saccharothrix sp. This actinobacterial strain was isolated from the rhizosphere of lupine plants growing in the extreme hyper-arid Atacama Desert. Structural characterization was carried out using electrospray ionization-mass spectrometry (ESI-MS) and NMR spectroscopy in combination with molecular modelling. The compound was tested against the ESKAPE pathogens, where it showed activity against MRSA and five strains associated with bovine mastitis, where it showed activity against Enterococcus pseudoavium and Staphylycoccus Aureus subsp. Aureus.en_US
dc.identifier.citationAstakala, R.V.; Preet, G.; Milne, B.F.; Tibyangye, J.; Razmilic, V.; Castro, J.F.; Asenjo, J.A.; Andrews, B.; Ebel, R.; Jaspars, M. (2022). Mutactimycin AP, a new Mutactimycin isolated from an actinobacteria from the Atacama Desert. Molecules. https://doi.org/10.3390/molecules27217185.en_US
dc.identifier.issn1420-3049
dc.identifier.urihttps://dir.muni.ac.ug/handle/20.500.12260/479
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.subjectSaccharothrixen_US
dc.subjectMutactimycinen_US
dc.subjectAnthracyclineen_US
dc.subjectGlycosideen_US
dc.subjectAnthraquinoneen_US
dc.subjectNMRen_US
dc.subjectMass spectrometryen_US
dc.subjectAntibioticsen_US
dc.subjectESKAPE pathogensen_US
dc.subjectBovine mastitisen_US
dc.subjectDairy cattleen_US
dc.titleMutactimycin AP, a new mutactimycin isolated from an actinobacteria from the Atacama Deserten_US
dc.typeArticleen_US

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