The diagnostic and prognostic role of miR-27a in cancer
| dc.contributor.author | Bi, Wen | |
| dc.contributor.author | Li, Jingjing | |
| dc.contributor.author | Xiong, Mengqiu | |
| dc.contributor.author | Pan, Bei | |
| dc.contributor.author | Zhang, Zhongqiu | |
| dc.contributor.author | Lubanga, Nasifu | |
| dc.contributor.author | He, Bangshun | |
| dc.contributor.author | Wang, Ping | |
| dc.date.accessioned | 2023-05-28T14:45:39Z | |
| dc.date.available | 2023-05-28T14:45:39Z | |
| dc.date.issued | 2023-05-22 | |
| dc.description.abstract | MicroRNA-27a (miR-27a) has been reported to be abnormally expressed in patients with cancer, and it could play potential roles as a diagnostic and prognostic biomarker of cancers. However, the diagnostic and prognostic role remains unclear. Hence, this meta-analysis, based on published data, was conducted to assess the utility of miR-27a as a diagnostic and prognostic marker in various cancers. To identify eligible studies, databases: Web of Science, PubMed, and CNKI were searched, with 868 literatures obtained, 16 of which were included in the Meta-analysis. The pooled results of studies conducted with serum/plasma showed that miR-27a was a valuable diagnostic biomarker in cancers (area under curve (AUC)= 0.91, sensitivity (SEN)= 0.84, specificity (SPE)= 0.85), with the diagnostic value slightly reduced in tumor tissue samples (AUC=0.83, SEN=0.78, SPE: 0.74). Additionally, the pooled results revealed that high expression of miR-27a predicted poor prognosis of cancer in serum/plasma (hazard ratio (HR) = 0.63, PHeterogeneity = 0.278, I2= 21.50%) but not in tumor tissue (HR = 0.98, PHeterogeneity =0.577, I2= 0.0). In brief, our results suggested that miR-27a in serum/plasma or tumor tissue could act as a diagnostic biomarker, and that miR-27a in serum/plasma could predict cancer patients’ survival. | en_US |
| dc.description.sponsorship | Jiangsu Provincial Medical Key Discipline Cultivation Unit (JSDW202239). Key Program of Natural Science Foundation of Wannan Medical College (WK2022Z04) | en_US |
| dc.identifier.citation | Bi, W., Li, J., Xiong, M., Pan, B., Zhang, Z., Lubanga, N., ... & Wang, P. (2023). The diagnostic and prognostic role of miR-27a in cancer. Pathology-Research and Practice, 154544. | en_US |
| dc.identifier.issn | 0344-0338 | |
| dc.identifier.uri | https://www.sciencedirect.com/science/article/abs/pii/S0344033823002443 | |
| dc.language.iso | en | en_US |
| dc.publisher | Elsevier | en_US |
| dc.subject | MicroRNA-27a | en_US |
| dc.subject | Cancer | en_US |
| dc.subject | Prognosis | en_US |
| dc.subject | Diagnosis | en_US |
| dc.title | The diagnostic and prognostic role of miR-27a in cancer | en_US |
| dc.type | Article | en_US |