The diagnostic and prognostic role of miR-27a in cancer

dc.contributor.authorBi, Wen
dc.contributor.authorLi, Jingjing
dc.contributor.authorXiong, Mengqiu
dc.contributor.authorPan, Bei
dc.contributor.authorZhang, Zhongqiu
dc.contributor.authorLubanga, Nasifu
dc.contributor.authorHe, Bangshun
dc.contributor.authorWang, Ping
dc.date.accessioned2023-05-28T14:45:39Z
dc.date.available2023-05-28T14:45:39Z
dc.date.issued2023-05-22
dc.description.abstractMicroRNA-27a (miR-27a) has been reported to be abnormally expressed in patients with cancer, and it could play potential roles as a diagnostic and prognostic biomarker of cancers. However, the diagnostic and prognostic role remains unclear. Hence, this meta-analysis, based on published data, was conducted to assess the utility of miR-27a as a diagnostic and prognostic marker in various cancers. To identify eligible studies, databases: Web of Science, PubMed, and CNKI were searched, with 868 literatures obtained, 16 of which were included in the Meta-analysis. The pooled results of studies conducted with serum/plasma showed that miR-27a was a valuable diagnostic biomarker in cancers (area under curve (AUC)= 0.91, sensitivity (SEN)= 0.84, specificity (SPE)= 0.85), with the diagnostic value slightly reduced in tumor tissue samples (AUC=0.83, SEN=0.78, SPE: 0.74). Additionally, the pooled results revealed that high expression of miR-27a predicted poor prognosis of cancer in serum/plasma (hazard ratio (HR) = 0.63, PHeterogeneity = 0.278, I2= 21.50%) but not in tumor tissue (HR = 0.98, PHeterogeneity =0.577, I2= 0.0). In brief, our results suggested that miR-27a in serum/plasma or tumor tissue could act as a diagnostic biomarker, and that miR-27a in serum/plasma could predict cancer patients’ survival.en_US
dc.description.sponsorshipJiangsu Provincial Medical Key Discipline Cultivation Unit (JSDW202239). Key Program of Natural Science Foundation of Wannan Medical College (WK2022Z04)en_US
dc.identifier.citationBi, W., Li, J., Xiong, M., Pan, B., Zhang, Z., Lubanga, N., ... & Wang, P. (2023). The diagnostic and prognostic role of miR-27a in cancer. Pathology-Research and Practice, 154544.en_US
dc.identifier.issn0344-0338
dc.identifier.urihttps://www.sciencedirect.com/science/article/abs/pii/S0344033823002443
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.subjectMicroRNA-27aen_US
dc.subjectCanceren_US
dc.subjectPrognosisen_US
dc.subjectDiagnosisen_US
dc.titleThe diagnostic and prognostic role of miR-27a in canceren_US
dc.typeArticleen_US

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