Draft genome of Orthopoxvirus monkeypox virus hMpxV/Uganda/MUWRP-H1922SL/2025 detected in Uganda

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dc.contributor.authorAlafi, Stephen
dc.contributor.authorWokorach, Godfrey
dc.contributor.authorTugume, Titus
dc.contributor.authorErima, Bernard
dc.contributor.authorMworozi, Edison A.
dc.contributor.authorsensamba, Jude T. S
dc.contributor.authorKiyengo, James
dc.contributor.authorKibuuka, Hannah
dc.contributor.authorMusinguzi, Ambrose K.
dc.contributor.authorKoehler, Jeffrey W.
dc.contributor.authorichardson, Joshua B. R
dc.contributor.authorPaola, Nicholas Di
dc.contributor.authorKugelman, Jeffrey
dc.contributor.authorWabwire-Mangen, Fred
dc.contributor.authorByarugaba, Denis K.
dc.date.accessioned2026-07-03T13:08:23Z
dc.date.available2026-07-03T13:08:23Z
dc.date.issued2026-06-15
dc.descriptionThis study contributes to Sustainable Development Goal (SDG) 3 (Good Health and Well-being), Target 3.3, by enhancing the tracking and response to infectious diseases such as mpox. It further advances SDG 9 (Industry, Innovation and Infrastructure), Target 9.5, by developing genomic sequencing and analysis capabilities to improve understanding of pathogens. Regarding SDG 17 (Partnerships for the Goals), Target 17.6, the research promotes scientific collaboration and data sharing to reinforce global health security. Within Uganda’s National Development Plan IV, the study supports the Human Capital Development Programme by prioritizing health security, disease prevention, and epidemic preparedness. It also aligns with the Science, Technology and Innovation Programme, which seeks to strengthen biomedical research and diagnostic competencies. By identifying and analyzing a Clade Ib mpox virus strain, the study provides critical evidence to inform outbreak preparedness, enhance surveillance, and guide public health decision-making. Additionally, it supports policy initiatives for genomic surveillance, cross-border disease control, and improved laboratory capacity for epidemic response.
dc.description.abstractMpox virus from Clade I exhibits high virulence and poses significant mortality risks, especially among children. We isolated a strain of the mpox virus (hMpxV/Uganda/MUWRP-H1922SL/2025) from an adult woman in Uganda. Using phylogenetic tree analysis and PoxServer evaluation, we determined that this strain belongs to Clade/Lineage Ib.
dc.description.sponsorshipArmed Forces Health Surveillance Branch (AFHSB), Global Emerging Infections Surveillance (GEIS) Section under ProMIS ID P0139_24_KY and P0118-24-RD.
dc.identifier.citationAlafi, S., Wokorach, G., Tugume, T., Erima, B., Mworozi, E. A., Ssensamba, J. T., ... & Byarugaba, D. K. (2026). Draft genome of Orthopoxvirus monkeypox virus hMpxV/Uganda/MUWRP-H1922SL/2025 detected in Uganda. Microbiology Resource Announcements, e01408-25.
dc.identifier.issn2576-098X
dc.identifier.urihttps://dir.muni.ac.ug/handle/20.500.12260/1009
dc.language.isoen
dc.publisherAmerican Society for Microbiology
dc.subjectMpox
dc.subjectPoxviridae
dc.subjectOrthopoxvirus
dc.titleDraft genome of Orthopoxvirus monkeypox virus hMpxV/Uganda/MUWRP-H1922SL/2025 detected in Uganda
dc.typeArticle

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