Progression from uncomplicated to severe malaria among children in settings receiving different malaria control interventions in sub-Saharan Africa: a systematic review protocol

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dc.contributor.authorOkek, Erick Jacob
dc.contributor.authorLutwama, Julius
dc.contributor.authorKinengyere, Alison Annet
dc.contributor.authorAsio, Juliet
dc.contributor.authorAwor, Silvia
dc.contributor.authorLe Doare, Kirsty
dc.contributor.authorMusinguzi, Benson
dc.contributor.authorSande, James Obondo
dc.contributor.authorOcan, Moses
dc.contributor.authorKayondo, Jonathan
dc.date.accessioned2025-09-17T14:19:07Z
dc.date.available2025-09-17T14:19:07Z
dc.date.issued2025-08-11
dc.description.abstractBackground Different malaria control measures are deployed simultaneously in endemic settings globally, with varying impacts on malaria burden. In sub-Saharan Africa, which bears the greatest burden of malaria, evidence on the impact of implementing various control interventions on malaria immunity remains unknown. This systematic review seeks to collate evidence on the extent of progression from uncomplicated to severe malaria among populations in sub-Saharan Africa settings receiving concurrent deployment of various malaria control measures. Methods The review will use a priori criteria contained in the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols. An experienced librarian (AAK) will independently search for articles from the following databases: PubMed, Web of Science, Embase, Scopus and Google Scholar. Boolean operators ‘AND’ and ‘OR’ will be used in the article search. Identified articles will be managed using EndNote. Article screening for inclusion and data extraction will be done in duplicate by two reviewers (EJO, and BM). Data extraction tools will be developed and customised in Excel. Data will be analysed using both narrative and quantitative synthesis. The level of heterogeneity between study outcomes will be measured using the I2 statistic. Subgroup analysis will be conducted to explore heterogeneity and establish the impact of different control interventions on progression from uncomplicated to severe malaria. A full systematic review and meta-analysis is expected to be ready for dissemination by the end of December 2025.
dc.identifier.citationIzudi J, Bajunirwe F, Cattamanchi A, West N (2025) Appropriateness, barriers, and facilitators of multi-month dispensing of tuberculosis drugs in rural eastern Uganda: A qualitative study to inform a non-inferiority randomized trial. PLOS Glob Public Health 5(9): e0004539. https://doi.org/10.1371/journal.pgph.0004539
dc.identifier.issn2044-6055
dc.identifier.urihttps://dir.muni.ac.ug/handle/20.500.12260/774
dc.language.isoen
dc.publisherBMJ Group
dc.subjectProgression
dc.subjectSevere malaria
dc.subjectINTERDISCIPLINARY RESEARCH AREAS::Children
dc.subjectMalaria control
dc.subjectSub-Saharan Africa
dc.titleProgression from uncomplicated to severe malaria among children in settings receiving different malaria control interventions in sub-Saharan Africa: a systematic review protocol
dc.typeArticle

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