Pou2f3 modulates mosquito host-seeking behavior by regulating skin microbiota and their production of volatiles: Implications for eco-friendly pest control strategies

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dc.contributor.authorWang, Hui
dc.contributor.authorRuixi, Qian
dc.contributor.authorWang, Yuxiang
dc.contributor.authorLi, Lanxi
dc.contributor.authorWu, Wenxuan
dc.contributor.authorChen, Yunxuan
dc.contributor.authorLi, Wenqing
dc.contributor.authorWijewardana, Chanuka Nisalanka
dc.contributor.authorZhou, Yinghui
dc.contributor.authorPadde, John Roberts
dc.contributor.authorWang, Yuxiang
dc.contributor.authorHou, Min
dc.contributor.authorXu, Zhipeng
dc.contributor.authorJi, MinJun
dc.contributor.authorChen, Lu
dc.contributor.authorChen, Lin
dc.date.accessioned2025-07-01T14:00:56Z
dc.date.available2025-07-01T14:00:56Z
dc.date.issued2025-06-26
dc.description.abstractSkin microbiota-derived volatile metabolites are critical for mosquito host-seeking and disease transmission. Similar volatile organic compounds (VOCs)-mediated mechanisms may apply to agricultural pests (e.g., aphids, whiteflies). We demonstrate that Pou2f3, a skin-enriched transcription factor, regulates β-defensin1 expression, shaping microbiota composition and volatile production. Pou2f3-deficient mice exhibited increased Staphylococcus abundance and elevated 1-methoxy-2-propanol levels, enhancing attraction in Culex and Aedes mosquitoes. This VOC, alongside other microbiota-derived compounds, could inspire targeted attractants for eco-friendly pest control via species-specific lures in integrated pest management (IPM). By bridging medical entomology and agricultural chemistry, this work advances sustainable solutions against vector-borne diseases and agricultural pests through precision chemical ecology strategies.
dc.identifier.citationWang, H., Qian, R., Wang, Y., Li, L., Wu, W., Chen, Y., ... & Chen, L. (2025). Pou2f3 Modulates Mosquito Host-Seeking Behavior by Regulating Skin Microbiota and Their Production of Volatiles: Implications for Eco-Friendly Pest Control Strategies. Journal of Agricultural and Food Chemistry. https://doi.org/10.1021/acs.jafc.5c03120
dc.identifier.issn1520-5118
dc.identifier.urihttps://dir.muni.ac.ug/handle/20.500.12260/757
dc.language.isoen
dc.publisherACS Publications
dc.subjectPou2f3
dc.subjectMosquito
dc.subjectHost-seeking behavior
dc.subjectSkin microbiota
dc.subjectVolatiles
dc.titlePou2f3 modulates mosquito host-seeking behavior by regulating skin microbiota and their production of volatiles: Implications for eco-friendly pest control strategies
dc.typeArticle

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