Novel anti-inflammatory peptide alleviates liver ischemia-reperfusion injury

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dc.contributor.authorXu, Xuejun
dc.contributor.authorSun, Kaineng
dc.contributor.authorChang, Hao
dc.contributor.authorShen, Chunxiang
dc.contributor.authorLi, Xiangdong
dc.contributor.authorNi, Yangyue
dc.contributor.authorZhu, Yuxiao
dc.contributor.authorWang, Huiquan
dc.contributor.authorXiong, Ruiyan
dc.contributor.authorPadde, Jon Rob
dc.contributor.authorXu, Zhipeng
dc.contributor.authorChen, Lin
dc.contributor.authorChen, Lu
dc.contributor.authorHou, Min
dc.contributor.authorPu, Liyong
dc.contributor.authorJi, Minjun
dc.date.accessioned2024-10-17T08:42:18Z
dc.date.available2024-10-17T08:42:18Z
dc.date.issued2024-04-30
dc.description.abstractIschemia-reperfusion injury (IRI) remains inevitable in liver surgeries, macrophages play a critical role in the development of IRI, but little is known about the macrophages regulate pathogenesis of IRI. Based on target guided screening, we identified a small 3 kDa peptide (SjDX5-271) from various schistosome egg-derived peptides that induced M2 macrophage polarization. SjDX5-271 treatment protected the mice against liver IRI through promoting M2 macrophage polarization, the protective effect was abrogated when the macrophages were depleted. Transcriptomic sequencing showed that the TLR signaling pathway was significantly inhibited in macrophages derived from the SjDX5-271 treatment group. We further identified that SjDX5-271 promotes M2 macrophage polarization by inhibiting the TLR4/MyD88/NF-κB signaling pathway and further alleviates hepatic inflammation in liver IRI. Collectively, SjDX5-271 exhibits promising therapeutic effects in IRI and represents a novel therapeutic approach for IRI, even in immune-related diseases. This study revealed the development of a new biologic from the parasite and enhanced our understanding of host-parasite interplay, providing a blueprint for future therapies for immune-related diseases.
dc.description.sponsorshipNational Natural Science Foundation of China (Grant No. 81971965).
dc.identifier.citationXu, X., Sun, K., Chang, H., Shen, C., Li, X., Ni, Y., ... & Ji, M. (2024). Novel anti-inflammatory peptide alleviates liver ischemia-reperfusion injury. The Journal of Biomedical Research. https://doi.org/10.7555/JBR.38.20240020
dc.identifier.issn1674-8301
dc.identifier.urihttps://dir.muni.ac.ug/handle/20.500.12260/694
dc.language.isoen
dc.publisherJournal of Biomedical Research
dc.subjectSchistosome-derived peptide
dc.subjectLiver ischemia-reperfusion injury
dc.subjectMacrophage
dc.subjectToll-like receptor-4
dc.titleNovel anti-inflammatory peptide alleviates liver ischemia-reperfusion injury
dc.typeArticle

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