Browsing by Author "Wasswaa, John"

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    Organochlorine pesticides in placenta, blood and breast milk of mothers in Uganda: Concentrations and health risks to breast fed infants
    (Elsevier, 2025-12-03) Omoding, Daniel; Nantumea, Teddy; Wasswaa, John; Odongo, Silver; Kyarimpa, Christine; Karumea, Ibrahim; Matovu, Henry; Sillanp, Mika; Kato, Charles Drago; Nabuumaa, Josephine; Miiroa, Ashirafu; Ssebugerea, Patrick
    Exposure to organochlorine pesticides (OCPs) remains a major public health concern in low-income countries, where historical usage and poor regulation continue to result in maternal and early-life exposures. This study assessed concentration profiles of selected OCPs, namely; p,p′-DDT, p,p′-DDE, o,p′-DDE, p,p′-DDD, o,p′-DDD, aldrin, dieldrin, lindane, α-endosulfan, β-endosulfan, and endosulfan-sulfate in maternal blood, breast milk, and placenta samples collected from 52 healthy mothers residing in the rural Kanungu District and urban Kampala District in Uganda. Analytical quantification was performed using gas chromatography-electron capture detection (GC-ECD), and compound identity was confirmed by gas chromatography–mass spectrometry (GC-MS). Concentrations of total DDTs (∑DDTs) were 63.0, 27.1, and 35.0 ng g-1 lipid weight (l.w) in blood, breast milk, and placenta, respectively. o,p′-DDE was the predominant metabolite in blood (67% of ∑DDTs), while p,p′-DDE dominated in placenta and milk (34% and 70%, respectively), possibly due to degradation of technical DDT applied in past decades. Other OCPs were generally low (