Research Articles: Recent submissions
Now showing items 1-20 of 28
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Plasmodium falciparum genetic diversity and multiplicity of infection based on msp-1, msp-2, glurp and microsatellite genetic markers in sub-Saharan Africa: a systematic review and meta-analysis
(Springer Nature, 2024-04-08)In sub-Saharan Africa (SSA), Plasmodium falciparum causes most of the malaria cases. Despite its crucial roles in disease severity and drug resistance, comprehensive data on Plasmodium falciparum genetic diversity and ... -
The impact of environmental and host factors on wolbachia density and efficacy as a biological tool
(Decoding Infection and Transmission, 2023-11-15)Wolbachia, a bacterium found naturally in some species of Aedes and Culex mosquitoes, has gained significant attention for it's potential in controlling mosquito-borne diseases and suppressing mosquito populations. However, ... -
A target-based discovery from a parasitic helminth as a novel therapeutic approach for autoimmune diseases.
(eBioMedicine, 2023-08-12)Background: Regulatory T cells (Tregs) can alleviate the development of autoimmune and inflammatory diseases, thereby proposing their role as a new therapeutic strategy. Parasitic helminths have co-evolved with hosts to ... -
Investigating metabolic and molecular ecological evolution of opportunistic pulmonary fungal coinfections: protocol for a laboratory-based cross-sectional study
(JMIR Publications, 2023-04-09)Background: Fungal-bacterial cocolonization and coinfections pose an emerging challenge among patients suspected of having pulmonary tuberculosis (PTB); however, the underlying pathogenic mechanisms and microbiome ... -
“I don’t support It for my children”: perceptions of parents and guardians regarding the use of modern contraceptives by adolescents in Arua City, Uganda
(Hindawi, 2023-04-03)Despite the high rates of adolescent pregnancies, the utilization of modern contraceptives is still low among adolescents in Uganda which highlights a missed opportunity for the prevention of unwanted pregnancies among ... -
Single Nucleotide Variants (SNVs) of Angiotensin-Converting Enzymes (ACE1 and ACE2):
(Sage Publishing, 2023-04-03)Background. Although it is common knowledge that the coronavirus disease of 2019 (COVID-19) and other viral infections have an uneven impact globally, the reasons for this are still indistinct. The absence of equivalent ... -
High prevalence of malaria in pregnancy among women attending antenatal care at a large referral hospital in northwestern Uganda:
(PLOS One, 2023-04-05)Background Malaria in pregnancy contributes to substantial morbidity and mortality among women in Uganda. However, there is limited information on the prevalence and factors associated with malaria in pregnancy among women ... -
Factors associated with continuity of care in hypertension and type 2 diabetes among forcibly displaced persons in the Bidibidi refugee settlement in Uganda: Protocol for a cross-sectional, mixed-methods study
(Elsevier, 2023-03-02)Background: Non-communicable diseases in humanitarian settings are generally under-researched, particularly in Africa and have been called a neglected crisis. Little is known about factors affecting access to and (dis)continuity ... -
Persistent malnutrition among children under five in pastoral communities of Aweil centre, South Sudan
(International Journal of Scientific Research and Management (IJSRM), 2023-03)Malnutrition is one of the leading causes of morbidity and mortality among children globally, and has been linked to 60% of the 10.9M deaths annually of under-fives. High prevalence of infectious diseases contributes to ... -
Green tea silver nanoparticles improve physiological motor and cognitive function in BALB/c mice during inflammation
(Elsevier, 2023-02-21)Information on the basic changes associated with green tea small molecules in acute inflammation is deficient. The purpose of the study was to characterize and establish the effects of green tea silver nanoparticles (AgNPs) ... -
Assessment of biosafety and biorisk management practices among medical laboratory students in two institutions in Uganda
(Elsevier, 2022-09-07)Medical laboratory workers handle clinical specimens, which are a threat of exposure to infectious agents. Notably, medical laboratory science students report for internships with only theoretical knowledge of biosafety ... -
Mutactimycin AP, a new mutactimycin isolated from an actinobacteria from the Atacama Desert
(MDPI, 2022-10-24)Bacteria belonging to the phylum Actinobacteria are a very good source of antibiotics, and indeed dominate the current clinical antibiotic space. This paper reports Mutactimycin AP, a new compound belonging to an ... -
Ethnicity, gender, and migration status:
(Wolters Kluwer Health, 2022-07-29)Globally, 298,000 women die due to pregnancy related causes and half of this occurs in Africa. In Uganda, maternal mortality has marginally reduced from 526 to 336 per 100,000 live births between 2001 and 2016. Health ... -
In-vivo efficacy profiles of plasmodium falciparum to Artemether- Lumefantrine, the recommended first-line treatment of uncomplicated Malaria in Kisii County Kenya
(South Asian Journal of Parasitology, 2021)Place and Duration of the Study: This study was carried out in Kisii County, Kenya in 2021, during the months of February to June. Methodology: Multi-stage random sampling was used. Participants suspected to be having ... -
Bacteriological profile, antibiotic susceptibility and factors associated with neonatal Septicaemia at Kilembe mines hospital, Kasese District Western Uganda
(Springer Nature, 2021-11-04)Neonatal septicaemia is one of the most common leading causes of neonatal morbidity and mortality in developing countries. It is estimated to affect more than 30 million people worldwide annually, potentially leading to 6 ... -
Status of pulmonary fungal pathogens among individuals with clinical features of pulmonary tuberculosis at Mbarara University Teaching Hospital in Southwestern Uganda
(SAGE Publications, 2021-08-31)Pulmonary mycoses are important diseases of the respiratory tract caused by pulmonary fungal pathogens. These pathogens are responsible for significant morbidity and mortality rates worldwide; however, less attention has ... -
Assessment of alternative approaches of primary cervical cancer screening among women in low-income environments
(Journal of Cancer Research and Experimental Oncology, 2021-01)Alternative techniques for detecting cancer of the cervix uteri alongside its early precancerous lesions still remain necessary for low income environments since morbidity and mortality due to cervical cancer continues to ... -
The anti-mycobacterial activity and safety profile of selected Crinum species in north western Uganda.
(Global Scientific Journals, 2021-06)Crinum species is a source of many bioactive molecules with both antimicrobial and anti-tumor properties. Chloroform, methanol and aqueous extracts of Crinum scabrum and Crinum macowanii bulbs and leaves were investigated ... -
Unsatisfactory COVID-19-related knowledge, attitudes and practices among undergraduate university students in Uganda: an online cross-sectional survey
(Scientific Research Publishing, 2021-06)This study examined the COVID-19-related knowledge, attitude and practices among undergraduate students in Uganda. An online cross-sectional survey was conducted from 12th-19th June 2020 among undergraduate students using ... -
Nurse managers’ perspectives on care quality and safety in rural hospitals in Uganda.
(Unisa Press Journals, 2020-09-09)Rural hospitals in sub-Saharan African countries play a key role in dealing with a high level of disease burden, but are usually poorly equipped with resources. Ward nurse managers in rural hospitals are in an ideal position ...