Bi, WenLi, JingjingXiong, MengqiuLubanga, NasifuTan, MingjuanTai, PingJin, QingZhang, LingyunZhu, ChengbinHe, Bangshun2024-11-202024-11-202024-04-24Bi, W., Li, J., Xiong, M., Nasifu, L., Tan, M., Tai, P., ... & He, B. (2024). EGR3 polymorphism is a potential susceptibility factor of schizophrenia risk in a Chinese population. Genetic Testing and Molecular Biomarkers, 28(4), 144-150.1945-0257https://dir.muni.ac.ug/handle/20.500.12260/704Objective: The purpose of this study was to evaluate the association between the single nucleotide polymorphisms (SNPs) (EGR3 rs1996147; EGR4 rs3813226, rs6747506; ERBB3 rs2292238; and ERBB4 rs707284, rs7560730) and the risk of schizophrenia (SZ) in a Chinese population. Materials and Methods: We conducted a case–control study, including 248 patients with SZ and 236 healthy controls matched for age and sex. The Mass-array platform was used to detect all the genotypes of the SNPs. Results: The results revealed that the EGR3 rs1996147 AA genotype was associated with borderline decreased SZ risk (AA vs. GG: adjusted OR = 0.43, 95% CI: 0.18–1.02, p = 0.06). However, no significant correlation was found between the other SNPs and overall SZ risk. Subgroup analysis also failed to show any significant association between all SNPs and the risk of SZ. Conclusion: In summary, this study revealed that the EGR3 rs1996147 AA genotype was associated with a borderline risk for SZ.enschizophreniapolymorphismsingle nucleotide polymorphismsgenotypesArticle